Description
Serum amyloid A-1 protein which belongs to the SAA family is encoded by the SAA1 gene in humans. It is expressed by the liver and secreted in plasma. Serum amyloid A-1 is the major acute phase reactant and apolipoprotein of the HDL complex. Elevated serum SAA1 protein levels may be associated with lung cancer. The level of Apo-SAA1, normally 1-5 µg/ml in plasma increases 500-1000 fold within 24 hrs of an inflammatory stimulus and under these conditions is the most abundant HDL Apo-lipoprotein